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Rapid progression of acquired amegakaryocytic thrombocytopenia to myelodysplastic syndrome: case report
Acquired amegakaryocytic thrombocytopenia (AAT) is a rare disease characterized by severe thrombocytopenia due to selective reduction or absence of megakaryocytes in the bone marrow. More commonly, patients with AAT have additional hematologic abnormalities such as macrocytosis or dyserythropoiesis, abnormalities which may predict progression to aplastic anemia or myelodysplasia. A 52-year-old female was admitted to hospital with mucosal and gingival bleeding. Megakaryocytes were not seen on the bone marrow aspiration and biopsy. AAT was diagnosed. Although she was treated with immunosuppressive therapy including prednisolone and cyclosporine, her disease progressed to myelodysplastic syndrome. She died at the third month of diagnosis because of cerebral bleeding.

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Authors: Mehmet Ali Erkurt, Emin Kaya, Murat Baran, Ece Yitmen, Soner Şenel, İrfan Kuku, İsmet Aydoğdu

Keywords: Kazanılmış amegakaryositik trombositopeni, Miyelodisplastik sendrom.

  • Year: 2005
  • Number: 4
  • Referance No: 60532
  • Figure 1. The bone marrow aspiration; normal cellularity and absence of megakaryocytes (wright stain 40x).

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